:root {
  --ink: #10272d;
  --ink-2: #17383f;
  --muted: #607579;
  --teal: #09aaa8;
  --teal-dark: #087b7a;
  --teal-pale: #e8f8f7;
  --orange: #f28a22;
  --line: #dce7e6;
  --paper: #ffffff;
  --soft: #f4f8f7;
  --max: 1240px;
  --pad: max(24px, calc((100vw - var(--max)) / 2));
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 116px; }
body { margin: 0; color: var(--ink); background: var(--paper); font-family: "PingFang SC", "Microsoft YaHei", "Noto Sans CJK SC", Inter, Arial, sans-serif; -webkit-font-smoothing: antialiased; }
a { color: inherit; text-decoration: none; }
button { font: inherit; }
.skip-link { position: fixed; left: 12px; top: -80px; z-index: 1000; color: #fff; background: var(--ink); padding: 12px 18px; }
.skip-link:focus { top: 12px; }

.site-header { position: fixed; inset: 0 0 auto; z-index: 100; background: rgba(255,255,255,.96); border-bottom: 1px solid transparent; transition: .2s; }
.site-header.scrolled { border-color: var(--line); backdrop-filter: blur(16px); }
.utility-bar { height: 31px; color: #d9eeee; background: var(--ink); }
.utility-shell { height: 100%; max-width: var(--max); margin: auto; padding: 0 24px; display: flex; align-items: center; justify-content: space-between; font-size: 10px; letter-spacing: .08em; }
.utility-shell nav { display: flex; align-items: center; gap: 20px; }
.utility-shell a:hover { color: #fff; }
.lang-toggle { border: 0; color: #fff; background: transparent; cursor: pointer; font-size: 10px; font-weight: 800; letter-spacing: .12em; padding: 4px 0; }
.nav-shell { height: 78px; max-width: var(--max); margin: auto; padding: 0 24px; display: flex; align-items: center; gap: 34px; }
.brand { margin-right: auto; }
.brand img { display: block; width: 168px; height: auto; }
.desktop-nav { display: flex; align-items: center; gap: 25px; }
.desktop-nav > a, .nav-dropdown > button { position: relative; border: 0; background: transparent; color: var(--ink); font-size: 13px; font-weight: 650; white-space: nowrap; cursor: pointer; padding: 28px 0; }
.desktop-nav > a::after, .nav-dropdown > button::after { content: ""; position: absolute; left: 0; right: 100%; bottom: 18px; height: 2px; background: var(--teal); transition: .2s; }
.desktop-nav > a:hover::after, .nav-dropdown:hover > button::after, .nav-dropdown:focus-within > button::after { right: 0; }
.nav-dropdown { position: relative; }
.nav-dropdown > button { display: flex; gap: 7px; align-items: center; }
.nav-dropdown > button i { color: var(--teal); font-style: normal; font-size: 14px; }
.dropdown-panel { position: absolute; top: 72px; left: -60px; width: 420px; visibility: hidden; opacity: 0; transform: translateY(8px); background: #fff; border-top: 3px solid var(--teal); box-shadow: 0 22px 60px rgba(16,39,45,.18); padding: 12px; transition: .18s; }
.nav-dropdown:hover .dropdown-panel, .nav-dropdown:focus-within .dropdown-panel { visibility: visible; opacity: 1; transform: none; }
.dropdown-panel a { display: flex; gap: 18px; align-items: center; padding: 15px; border-bottom: 1px solid var(--line); }
.dropdown-panel a:last-child { border-bottom: 0; }
.dropdown-panel a:hover { background: var(--soft); }
.dropdown-panel a > span { color: var(--orange); font-size: 10px; font-weight: 800; }
.dropdown-panel strong, .dropdown-panel small { display: block; }
.dropdown-panel strong { font-size: 14px; }
.dropdown-panel small { margin-top: 4px; color: #8ba0a3; font-size: 10px; letter-spacing: .04em; }
.menu-toggle { display: none; border: 0; background: none; width: 42px; height: 42px; cursor: pointer; }
.menu-toggle span { display: block; width: 22px; height: 2px; margin: 5px auto; background: var(--ink); }
.mobile-nav { display: none; }

.banner { margin-top: 109px; padding-top: 26px; background: #edf9fa; border-bottom: 1px solid var(--line); }
.banner > img { display: block; width: min(100%, 1080px); height: auto; margin: 0 auto; }
.banner-actions { display: flex; justify-content: flex-end; gap: 12px; max-width: 1080px; margin: -28px auto 0; padding: 0 24px 26px; position: relative; }
.button { min-height: 54px; padding: 0 24px; display: inline-flex; align-items: center; justify-content: center; gap: 28px; border: 1px solid var(--ink); font-size: 13px; font-weight: 800; transition: .2s; }
.button:hover { transform: translateY(-2px); }
.button.primary { color: #fff; border-color: var(--teal); background: var(--teal); }
.button.secondary { background: #fff; }
.button.white { color: var(--ink); border-color: #fff; background: #fff; }

.section { padding: 112px var(--pad); }
.section-kicker { display: flex; align-items: center; gap: 12px; color: var(--teal-dark); font-size: 11px; font-weight: 800; letter-spacing: .14em; text-transform: uppercase; }
.section-kicker > span:first-child { color: var(--orange); }
.section-kicker.light { color: #b5e6e4; }
.section h1, .section h2 { letter-spacing: -.04em; }
.strategy-head, .about-grid, .ai-head, .pipeline-head, .progress-head { display: grid; grid-template-columns: 1fr 1fr; gap: 8vw; align-items: start; margin-top: 36px; }
.strategy-head h1, .about-grid h2, .ai-head h2, .pipeline-head h2, .progress-head h2 { margin: 0; font-size: clamp(38px, 4vw, 60px); line-height: 1.18; }
.strategy-head p, .about-grid p, .ai-head p, .pipeline-head p, .progress-head p { margin: 4px 0 0; color: var(--muted); font-size: 15px; line-height: 1.95; }

.strategy-grid { display: grid; grid-template-columns: repeat(5, 1fr); margin-top: 72px; border-top: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.strategy-card { position: relative; min-height: 315px; padding: 28px 26px; border-right: 1px solid var(--line); transition: .22s; }
.strategy-card:first-child { border-left: 1px solid var(--line); }
.strategy-card:hover { color: #fff; background: var(--ink); transform: translateY(-5px); }
.strategy-card.accent { background: var(--teal-pale); }
.strategy-card.accent:hover { background: var(--teal); }
.strategy-card.gd-accent { color: #fff; background: linear-gradient(145deg, #103c45, #096f73); }
.strategy-card.gd-accent p, .strategy-card.gd-accent em { color: #b9d8d9; }
.strategy-card.gd-accent > i { color: #ffad5d; }
.strategy-card .number { color: var(--orange); font-size: 10px; font-weight: 800; }
.strategy-card em { display: block; margin-top: 38px; color: #8ea1a4; font-size: 9px; font-style: normal; font-weight: 800; letter-spacing: .14em; }
.strategy-card h2 { margin: 14px 0 13px; font-size: 21px; line-height: 1.35; }
.strategy-card p { margin: 0; color: var(--muted); font-size: 12px; line-height: 1.8; }
.strategy-card:hover p, .strategy-card:hover em { color: #abc1c3; }
.strategy-card > i { position: absolute; right: 24px; bottom: 24px; color: var(--teal); font-style: normal; font-size: 21px; }
.strategy-card:hover > i { color: var(--orange); }

.about { background: var(--soft); }
.about-grid > div p + p { margin-top: 18px; }
.value-strip { display: grid; grid-template-columns: repeat(4, 1fr); margin-top: 68px; border-top: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.value-strip > div { padding: 25px 22px; border-right: 1px solid var(--line); }
.value-strip > div:first-child { border-left: 1px solid var(--line); }
.value-strip strong, .value-strip span { display: block; }
.value-strip strong { font-size: 15px; }
.value-strip span { margin-top: 8px; color: var(--muted); font-size: 11px; line-height: 1.6; }

.program { position: relative; display: grid; grid-template-columns: .8fr 1.2fr; gap: 8vw; overflow: hidden; }
.program-index { position: absolute; top: 46px; left: var(--pad); display: flex; gap: 12px; align-items: center; color: var(--muted); }
.program-index span { color: var(--orange); font-size: 11px; font-weight: 800; }
.program-index small { font-size: 10px; letter-spacing: .12em; }
.program-label { margin-bottom: 28px; color: var(--teal-dark); font-size: 10px; font-weight: 800; letter-spacing: .16em; }
.program-intro h2 { margin: 0; font-size: clamp(40px, 4.5vw, 64px); line-height: 1.08; }
.program-intro > p { margin: 30px 0 0; max-width: 540px; color: var(--muted); font-size: 14px; line-height: 1.9; }
.program-content { display: grid; grid-template-columns: 1fr 1fr; gap: 18px; }
.project-card { min-height: 320px; padding: 28px; border: 1px solid var(--line); background: #fff; }
.project-card.dark-card { color: #fff; background: var(--ink); border-color: var(--ink); }
.project-top { display: flex; justify-content: space-between; gap: 12px; font-size: 9px; font-weight: 800; letter-spacing: .1em; }
.project-top i { color: var(--teal); font-style: normal; }
.project-card h3 { margin: 44px 0 18px; font-size: 27px; }
.project-card > p { min-height: 74px; color: var(--muted); font-size: 12px; line-height: 1.8; }
.dark-card > p { color: #a9bec0; }
.project-card dl { margin: 30px 0 0; }
.project-card dl > div { display: flex; justify-content: space-between; gap: 20px; padding: 10px 0; border-top: 1px solid var(--line); }
.dark-card dl > div { border-color: rgba(255,255,255,.13); }
.project-card dt { color: #91a3a6; font-size: 10px; }
.project-card dd { margin: 0; font-size: 11px; font-weight: 700; }
.science-note { grid-column: 1 / -1; display: grid; grid-template-columns: 180px 1fr; gap: 24px; padding: 24px 28px; background: var(--teal-pale); }
.science-note strong { font-size: 13px; }
.science-note p { margin: 0; color: var(--muted); font-size: 12px; line-height: 1.7; }

.program-dark { color: #fff; background: var(--ink); }
.program-dark .program-label { color: #68dcd8; }
.program-dark .program-intro > p { color: #9eb6b8; }
.mechanism-panel { align-self: center; display: grid; grid-template-columns: 1fr 130px 1fr; align-items: center; row-gap: 38px; }
.mechanism-node { aspect-ratio: 1; border: 1px solid rgba(99,226,221,.35); border-radius: 50%; display: grid; place-content: center; text-align: center; background: radial-gradient(circle, rgba(9,170,168,.17), transparent 66%); }
.mechanism-node span { color: #fff; font-size: 31px; font-weight: 800; }
.mechanism-node small { margin-top: 8px; color: #95b5b7; font-size: 10px; }
.mechanism-link { display: flex; flex-direction: column; align-items: center; gap: 10px; color: var(--orange); text-align: center; font-size: 10px; }
.mechanism-link i { width: 100%; height: 1px; background: linear-gradient(90deg, transparent, var(--orange), transparent); }
.mechanism-result { grid-column: 1 / -1; padding: 24px; border-top: 1px solid rgba(255,255,255,.15); text-align: center; }
.mechanism-result strong { font-size: 17px; }
.mechanism-result p { max-width: 570px; margin: 10px auto 0; color: #94adaf; font-size: 12px; line-height: 1.7; }

.program-gdiga1 { color: #fff; background: linear-gradient(135deg, #09242b 0%, #0b343c 54%, #0a5b5e 100%); }
.program-gdiga1::after { content: "Gd-IgA1"; position: absolute; right: -22px; top: 40px; color: rgba(255,255,255,.035); font-size: clamp(88px, 15vw, 210px); font-weight: 900; letter-spacing: -.08em; pointer-events: none; }
.program-gdiga1 .program-index, .program-gdiga1 .program-intro > p { color: #a8c3c5; }
.program-gdiga1 .program-label { color: #78e0dd; }
.gd-status { display: inline-flex; flex-wrap: wrap; align-items: center; gap: 12px; margin-top: 28px; }
.gd-status span { padding: 8px 12px; color: #08272d; background: #6fe0dc; font-size: 9px; font-weight: 900; letter-spacing: .1em; }
.gd-status strong { color: #b9d0d2; font-size: 10px; font-weight: 650; }
.gd-pathway { position: relative; z-index: 1; grid-column: 1 / -1; display: grid; grid-template-columns: 1fr 42px 1fr 42px 1fr; align-items: stretch; gap: 12px; margin-top: 4px; }
.gd-step { min-height: 300px; padding: 28px; border: 1px solid rgba(137,226,222,.22); background: rgba(255,255,255,.045); }
.gd-step.primary-step { border-color: rgba(242,138,34,.7); background: linear-gradient(145deg, rgba(242,138,34,.12), rgba(255,255,255,.04)); }
.gd-step.future-step { border-color: rgba(111,224,220,.5); background: linear-gradient(145deg, rgba(9,170,168,.18), rgba(255,255,255,.04)); }
.gd-step > span { color: var(--orange); font-size: 9px; font-weight: 800; letter-spacing: .14em; }
.gd-step > strong { display: block; margin-top: 34px; font-size: 20px; line-height: 1.4; }
.gd-step > p { margin: 14px 0 0; color: #a9c0c2; font-size: 11px; line-height: 1.8; }
.gd-metric { display: flex; align-items: baseline; gap: 10px; margin-top: 20px; padding-top: 14px; border-top: 1px solid rgba(255,255,255,.13); }
.gd-metric b { color: #72dfdb; font-size: 30px; }
.gd-metric small { color: #b7cbcd; font-size: 9px; }
.gd-arrow { display: grid; place-items: center; color: #67d7d3; font-size: 24px; }
.gd-disclaimer { position: relative; z-index: 1; grid-column: 1 / -1; margin: 0; padding: 18px 22px; color: #aac0c2; border-left: 3px solid var(--orange); background: rgba(0,0,0,.16); font-size: 9px; line-height: 1.8; }

.program-aav { grid-template-columns: .75fr .85fr .7fr; gap: 5vw; background: linear-gradient(120deg, #fff, #f0faf9); }
.aav-visual { position: relative; min-height: 390px; }
.capsid { position: absolute; width: 142px; height: 142px; left: 50%; top: 50%; transform: translate(-50%,-50%); border: 1px solid #63dcd7; border-radius: 50%; display: grid; place-content: center; color: #fff; background: radial-gradient(circle at 35% 30%, #a1fcf8, var(--teal) 50%, var(--teal-dark)); box-shadow: 0 0 0 34px rgba(9,170,168,.06), 0 0 0 75px rgba(9,170,168,.035); font-weight: 900; letter-spacing: .1em; }
.receptor { position: absolute; color: var(--teal-dark); border-left: 3px solid var(--orange); padding-left: 10px; font-size: 10px; font-weight: 800; }
.r1 { top: 42px; left: 16px; }
.r2 { right: 5px; bottom: 54px; }
.route { position: absolute; left: 15%; right: 15%; top: 50%; border-top: 1px dashed rgba(9,170,168,.45); }
.aav-facts { align-self: center; }
.aav-facts > div { padding: 22px 0; border-bottom: 1px solid var(--line); }
.aav-facts > div:first-child { border-top: 1px solid var(--line); }
.aav-facts span { color: var(--orange); font-size: 9px; font-weight: 800; }
.aav-facts strong { display: block; margin-top: 10px; font-size: 16px; }
.aav-facts p { margin: 7px 0 0; color: var(--muted); font-size: 11px; line-height: 1.7; }
.aav-facts .validated { padding-left: 16px; border-left: 3px solid var(--teal); background: var(--teal-pale); }

.ai { color: #fff; background: #0a1e23; }
.ai-head p { color: #9db5b7; }
.ai-models { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; margin-top: 64px; }
.ai-models article { min-height: 300px; padding: 34px; border: 1px solid rgba(255,255,255,.15); background: rgba(255,255,255,.025); }
.model-code { color: var(--orange); font-size: 9px; font-weight: 800; letter-spacing: .14em; }
.ai-models h3 { margin: 48px 0 15px; font-size: 27px; }
.ai-models p { color: #98b0b2; font-size: 12px; line-height: 1.8; }
.tags { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 28px; }
.tags span { padding: 7px 10px; color: #a7d7d6; border: 1px solid rgba(99,226,221,.22); font-size: 9px; }
.complement-model { border-color: rgba(255,111,55,.42) !important; background: linear-gradient(145deg, rgba(255,111,55,.07), rgba(255,255,255,.02)) !important; }
.complitope-detail { margin-top: 20px; padding: 44px; border: 1px solid rgba(255,255,255,.15); background: #0d2630; }
.complitope-title { display: grid; grid-template-columns: 1.15fr 1fr; gap: 7vw; align-items: end; }
.complitope-title > div > span, .detail-number, .applications-head > span { color: var(--orange); font-size: 9px; font-weight: 800; letter-spacing: .14em; }
.complitope-title h3 { margin: 14px 0 0; font-size: clamp(28px, 3vw, 43px); line-height: 1.2; }
.complitope-title > p { margin: 0; color: #a8bdc0; font-size: 12px; line-height: 1.85; }
.complitope-metrics { display: grid; grid-template-columns: repeat(3, 1fr); margin-top: 38px; border: 1px solid rgba(255,255,255,.12); }
.complitope-metrics div { display: flex; align-items: baseline; gap: 12px; padding: 18px 22px; }
.complitope-metrics div + div { border-left: 1px solid rgba(255,255,255,.12); }
.complitope-metrics strong { color: #52d4d1; font-size: 30px; }
.complitope-metrics span { color: #a8bdc0; font-size: 10px; letter-spacing: .08em; }
.complitope-columns { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; margin-top: 20px; }
.complitope-columns article { padding: 30px; background: rgba(255,255,255,.035); border-top: 2px solid rgba(82,212,209,.5); }
.complitope-columns h4, .applications-head h4 { margin: 22px 0 12px; font-size: 20px; line-height: 1.45; }
.complitope-columns p { margin: 0; color: #9fb6b9; font-size: 11px; line-height: 1.85; }
.model-flow { display: flex; flex-wrap: wrap; align-items: center; gap: 8px; margin-top: 22px; }
.model-flow span { padding: 7px 9px; color: #d2eeee; border: 1px solid rgba(82,212,209,.25); font-size: 9px; }
.model-flow i, .model-flow b { color: var(--orange); font-size: 11px; font-style: normal; }
.complitope-modes { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; margin-top: 20px; }
.complitope-modes > div { padding: 25px 30px; border-left: 2px solid var(--orange); background: rgba(255,111,55,.045); }
.complitope-modes span { color: var(--orange); font-size: 8px; font-weight: 800; letter-spacing: .13em; }
.complitope-modes strong { display: block; margin-top: 10px; font-size: 15px; }
.complitope-modes p { margin: 7px 0 0; color: #9fb6b9; font-size: 10px; line-height: 1.7; }
.complitope-applications { margin-top: 20px; padding: 30px; color: var(--ink); background: #f2f6f8; }
.applications-head { display: flex; justify-content: space-between; align-items: flex-end; gap: 24px; padding-bottom: 22px; border-bottom: 1px solid #d8e2e5; }
.applications-head h4 { margin: 0; color: var(--ink); }
.application-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 0; }
.application-grid > div { min-height: 145px; padding: 24px 22px; border-bottom: 1px solid #d8e2e5; }
.application-grid > div:not(:nth-child(3n+1)) { border-left: 1px solid #d8e2e5; }
.application-grid strong { color: var(--orange); font-size: 10px; letter-spacing: .08em; }
.application-grid p { margin: 10px 0 0; color: #60767b; font-size: 10px; line-height: 1.65; }
.research-use { margin: 18px 0 0; color: #729096; font-size: 8px; letter-spacing: .1em; text-transform: uppercase; }
.data-loop { display: grid; grid-template-columns: repeat(7, auto); justify-content: center; align-items: center; gap: 22px; margin-top: 46px; color: #b7cdce; font-size: 11px; }
.data-loop i { color: var(--orange); font-style: normal; }

.pipeline-head h2 { margin-top: 30px; }
.pipeline-table { margin-top: 62px; border-top: 2px solid var(--ink); }
.pipeline-row { min-height: 88px; display: grid; grid-template-columns: 1.2fr 1.4fr .7fr; align-items: center; border-bottom: 1px solid var(--line); }
.pipeline-row > span { padding: 18px 24px; font-size: 13px; }
.pipeline-row > span + span { border-left: 1px solid var(--line); }
.header-row { min-height: 50px; background: var(--soft); }
.header-row span { color: var(--muted); font-size: 10px; font-weight: 800; letter-spacing: .08em; }
.pipeline-row strong, .pipeline-row small { display: block; }
.pipeline-row small { margin-top: 5px; color: #93a4a6; font-size: 9px; letter-spacing: .08em; }
.pipeline-row > span:last-child { display: flex; align-items: center; gap: 11px; }
.pipeline-row b { font-size: 11px; }
.pipeline-row.highlighted-row { background: linear-gradient(90deg, rgba(9,170,168,.1), rgba(9,170,168,.025)); box-shadow: inset 3px 0 0 var(--teal); }
.stage { width: 8px; height: 8px; border-radius: 50%; background: #9db1b2; box-shadow: 0 0 0 5px #eef2f2; }
.stage.validation { background: var(--orange); box-shadow: 0 0 0 5px #fff1e4; }

.progress { background: var(--soft); }
.progress-grid { display: grid; grid-template-columns: repeat(2, 1fr); gap: 18px; margin-top: 58px; }
.progress-grid article { position: relative; min-height: 275px; padding: 30px; border: 1px solid var(--line); background: #fff; }
.progress-grid article.research-feature { min-height: 365px; padding-bottom: 76px; }
.progress-grid article.featured { color: #fff; border-color: var(--teal); background: var(--teal); }
.progress-grid article > span { font-size: 9px; font-weight: 800; letter-spacing: .12em; }
.progress-grid h3 { margin: 60px 0 12px; font-size: 20px; }
.progress-grid p { color: var(--muted); font-size: 11px; line-height: 1.7; }
.progress-grid .featured p { color: #dafafa; }
.progress-grid small { display: block; margin-top: 18px; color: rgba(255,255,255,.76); font-size: 9px; line-height: 1.65; }
.research-link { display: inline-block; margin-top: 14px; color: #fff; border-bottom: 1px solid rgba(255,255,255,.46); font-size: 9px; font-weight: 750; line-height: 1.8; }
.research-link:hover { border-color: #fff; }
.progress-grid em { position: absolute; left: 30px; bottom: 28px; color: var(--teal-dark); font-size: 9px; font-style: normal; font-weight: 800; }
.progress-grid .featured em { color: #fff; }
.progress-grid article.gd-research { border-color: rgba(9,170,168,.55); background: linear-gradient(145deg, #fff, #edf9f8); }
.progress-grid article.gd-research small { color: #668084; }

.partnership { display: grid; grid-template-columns: 1fr .8fr; gap: 9vw; color: #fff; background: var(--teal); }
.partnership-copy h2 { margin: 33px 0 0; font-size: clamp(40px, 4.5vw, 64px); line-height: 1.12; }
.partnership-copy > p { max-width: 590px; margin: 28px 0 34px; color: #dcffff; font-size: 14px; line-height: 1.9; }
.partner-modes { border-top: 1px solid rgba(255,255,255,.38); align-self: center; }
.partner-modes > div { display: flex; align-items: center; gap: 24px; padding: 22px 4px; border-bottom: 1px solid rgba(255,255,255,.38); }
.partner-modes span { color: #b9eeee; font-size: 9px; }
.partner-modes strong { font-size: 15px; }

.careers-contact { display: grid; grid-template-columns: 1fr 1fr; gap: 9vw; }
.careers > span { color: var(--orange); font-size: 10px; font-weight: 800; letter-spacing: .15em; }
.careers h2 { max-width: 590px; margin: 32px 0 20px; font-size: 40px; line-height: 1.2; }
.careers p { color: var(--muted); font-size: 13px; line-height: 1.8; }
.careers a { display: inline-block; margin-top: 20px; color: var(--teal-dark); font-size: 12px; font-weight: 800; }
.contact-column { min-width: 0; }
.contact-map { position: relative; height: 310px; margin: 0 0 24px; overflow: hidden; border: 1px solid var(--line); background: #edf3f5; }
.contact-map::after { content: ""; position: absolute; inset: 0; background: linear-gradient(180deg, transparent 48%, rgba(6,28,34,.58)); pointer-events: none; }
.contact-map > img { display: block; width: 100%; height: 100%; object-fit: cover; object-position: 50% 48%; filter: saturate(.78) contrast(.96); transition: transform .45s ease; }
.contact-map:hover > img { transform: scale(1.025); }
.contact-map figcaption { position: absolute; z-index: 1; left: 22px; right: 22px; bottom: 20px; display: flex; align-items: center; gap: 15px; color: #fff; }
.contact-map figcaption div { display: grid; grid-template-columns: 1fr auto; column-gap: 16px; align-items: end; flex: 1; }
.contact-map figcaption small, .contact-map figcaption strong { display: block; grid-column: 1; }
.contact-map figcaption small { color: #b9eeee; font-size: 8px; font-weight: 800; letter-spacing: .14em; }
.contact-map figcaption strong { margin-top: 5px; font-size: 15px; }
.contact-map figcaption em { grid-column: 2; grid-row: 1 / 3; align-self: center; color: #d7eeee; font-size: 8px; font-style: normal; font-weight: 800; letter-spacing: .12em; }
.map-pin { position: relative; width: 38px; height: 38px; flex: 0 0 38px; border-radius: 50% 50% 50% 0; background: var(--orange); box-shadow: 0 8px 22px rgba(7,35,42,.35); transform: rotate(-45deg); }
.map-pin i { position: absolute; width: 12px; height: 12px; left: 13px; top: 13px; border-radius: 50%; background: #fff; }
.contact-card { border-top: 1px solid var(--line); }
.contact-card > div { display: grid; grid-template-columns: 120px 1fr; gap: 26px; padding: 22px 4px; border-bottom: 1px solid var(--line); }
.contact-card span { color: var(--muted); font-size: 10px; }
.contact-card strong { font-size: 13px; font-weight: 650; }

footer { padding: 50px var(--pad) 28px; background: #fff; }
.footer-top { display: flex; align-items: center; justify-content: space-between; }
.footer-top img { width: 184px; }
.footer-top p { color: var(--muted); font-size: 13px; }
.footer-links { display: flex; flex-wrap: wrap; gap: 26px; margin: 42px 0 25px; padding: 22px 0; border-top: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.footer-links a { color: var(--muted); font-size: 11px; }
.footer-links a:hover { color: var(--teal-dark); }
.footer-bottom { display: flex; justify-content: space-between; gap: 28px; color: #849496; font-size: 9px; line-height: 1.6; }

@media (max-width: 1060px) {
  .desktop-nav { gap: 17px; }
  .desktop-nav > a, .nav-dropdown > button { font-size: 11px; }
  .brand img { width: 146px; }
  .strategy-grid { grid-template-columns: repeat(2, 1fr); }
  .strategy-card:nth-child(3) { border-left: 1px solid var(--line); }
  .program-aav { grid-template-columns: 1fr 1fr; }
  .program-aav .aav-facts { grid-column: 1 / -1; display: grid; grid-template-columns: repeat(3, 1fr); }
  .aav-facts > div { padding: 22px 18px; border-top: 1px solid var(--line); border-right: 1px solid var(--line); }
}

@media (max-width: 900px) {
  html { scroll-padding-top: 78px; }
  .utility-bar, .desktop-nav { display: none; }
  .site-header { height: 76px; }
  .nav-shell { height: 76px; }
  .menu-toggle { display: block; }
  .site-header.open .mobile-nav { display: flex; }
  .mobile-nav { position: absolute; top: 76px; left: 0; right: 0; max-height: calc(100vh - 76px); overflow-y: auto; flex-direction: column; gap: 0; padding: 15px 24px 24px; background: #fff; border-bottom: 1px solid var(--line); box-shadow: 0 20px 50px rgba(16,39,45,.14); }
  .mobile-nav a { padding: 12px 0; border-bottom: 1px solid var(--line); font-size: 13px; font-weight: 700; }
  .mobile-nav a.sub { padding-left: 18px; color: var(--muted); font-size: 12px; }
  .mobile-group { padding: 18px 0 6px; color: var(--orange); font-size: 10px; font-weight: 800; letter-spacing: .12em; }
  .banner { margin-top: 76px; }
  .banner-actions { margin-top: 0; justify-content: center; padding-top: 20px; }
  .strategy-head, .about-grid, .ai-head, .pipeline-head, .progress-head, .program, .program-aav, .partnership, .careers-contact { grid-template-columns: 1fr; }
  .program { gap: 52px; }
  .program-index { top: 34px; }
  .program-content { grid-template-columns: 1fr 1fr; }
  .gd-pathway { grid-template-columns: 1fr; }
  .gd-arrow { min-height: 26px; transform: rotate(90deg); }
  .gd-step { min-height: 0; }
  .program-aav .aav-facts { grid-column: auto; }
  .ai-models { grid-template-columns: 1fr; }
  .complitope-title { grid-template-columns: 1fr; gap: 24px; }
  .application-grid { grid-template-columns: 1fr 1fr; }
  .application-grid > div:not(:nth-child(3n+1)) { border-left: 0; }
  .application-grid > div:nth-child(even) { border-left: 1px solid #d8e2e5; }
  .progress-grid { grid-template-columns: 1fr 1fr; }
  .progress-grid article.featured { grid-column: 1 / -1; }
  .partner-modes { margin-top: 16px; }
  .contact-map { height: 360px; }
}

@media (max-width: 620px) {
  .nav-shell { padding: 0 18px; }
  .brand img { width: 142px; }
  .banner { padding-top: 10px; }
  .banner > img { width: 100%; height: auto; }
  .banner-actions { flex-direction: column; padding: 16px 20px 24px; }
  .button { width: 100%; }
  .section { padding: 82px 20px; }
  .section h1, .section h2, .strategy-head h1, .about-grid h2, .ai-head h2, .pipeline-head h2, .progress-head h2 { font-size: 36px; }
  .strategy-grid { grid-template-columns: 1fr; margin-top: 48px; }
  .strategy-card, .strategy-card:nth-child(3) { border-left: 1px solid var(--line); border-bottom: 1px solid var(--line); }
  .strategy-card { min-height: 250px; }
  .value-strip { grid-template-columns: 1fr 1fr; }
  .value-strip > div:nth-child(3) { border-left: 1px solid var(--line); }
  .program-intro h2 { font-size: 40px; }
  .program-content { grid-template-columns: 1fr; }
  .science-note { grid-template-columns: 1fr; }
  .mechanism-panel { grid-template-columns: 1fr 65px 1fr; }
  .mechanism-node span { font-size: 23px; }
  .aav-visual { min-height: 320px; }
  .program-aav .aav-facts { display: block; }
  .complitope-detail { padding: 25px 18px; }
  .complitope-metrics, .complitope-columns, .complitope-modes, .application-grid { grid-template-columns: 1fr; }
  .complitope-metrics div + div { border-left: 0; border-top: 1px solid rgba(255,255,255,.12); }
  .application-grid > div:nth-child(even) { border-left: 0; }
  .applications-head { display: block; }
  .applications-head h4 { margin-top: 12px; }
  .data-loop { grid-template-columns: 1fr; justify-items: center; }
  .data-loop i { transform: rotate(90deg); }
  .pipeline-row { grid-template-columns: 1.2fr .8fr; }
  .pipeline-row > span:nth-child(2) { display: none; }
  .pipeline-row > span:last-child { border-left: 1px solid var(--line); }
  .progress-grid { grid-template-columns: 1fr; }
  .progress-grid article.featured { grid-column: auto; }
  .careers h2 { font-size: 34px; }
  .contact-map { height: 270px; margin-top: 18px; }
  .contact-map figcaption { left: 16px; right: 16px; bottom: 15px; }
  .contact-map figcaption em { display: none; }
  .contact-card > div { grid-template-columns: 1fr; gap: 7px; }
  .footer-top, .footer-bottom { flex-direction: column; align-items: flex-start; gap: 18px; }
  .footer-links { gap: 18px; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition: none !important; }
}